People with primary insomnia¹（失眠） may be able to find relief by wearing a cap that cools the brain during sleep, suggests a research abstract that will be presented Monday, June 13, in Minneapolis, Minn., at SLEEP 2011, the 25th Anniversary Meeting of the Associated Professional Sleep Societies LLC (APSS). According to the authors, a reduction in metabolism² in the brain's frontal cortex（皮质，树皮） occurs while falling asleep and is associated with restorative sleep. However, insomnia is associated with increased metabolism in this same brain region. One way to reduce cerebral³ metabolic⁴ activity is to use frontal cerebral thermal⁵ transfer to cool the brain, a process known as "cerebral hypothermia（降低体温） ."

Results show that there were linear effects of all-night thermal transfer intensities⁶ on sleep latency（潜伏，潜在因素） and sleep efficiency. The time that it took subjects with primary insomnia to fall asleep (13 minutes) and the percentage of time in bed that they slept (89 percent) during treatment at the maximal cooling intensity⁷ were similar to healthy controls (16 minutes and 89 percent).

"The most significant finding from this study is that we can have a beneficial impact on the sleep of insomnia patients via a safe, non-pharmaceutical mechanism⁸ that can be made widely available for home use by insomnia sufferers," said principal investigator⁹ and lead author Dr. Eric Nofzinger, professor and director of the Sleep Neuroimaging Research Program at the University of Pittsburgh School of Medicine. "The finding of a linear dose response effect of the treatment implies a direct beneficial impact on the neurobiology of insomnia that can improve the sleep of insomnia patients. We believe this has far-ranging implications for how insomnia can be managed in the future."

In this crossover study, Nofzinger and co-investigator Dr. Daniel Buysse screened 110 people, enrolling¹⁰ 12 people with primary insomnia and 12 healthy, age-and gender-matched controls. Participants with insomnia had an average age of about 45 years, and nine of the 12 subjects were women.

Participants received all-night frontal cerebral thermal transfer by wearing a soft plastic cap on their head. The cap contained tubes that were filled with circulating water. The effectiveness of varying thermal transfer intensities was investigated by implementing¹¹ multiple conditions: no cooling cap, and cooling cap with either neutral, moderate or maximal cooling intensity.