Genome sequence could bring woolly mammoth back to life
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Researchers have sequenced the gene1 map of a long-extinct, mummified woolly mammoth2, using DNA3 taken from its hair.

The sequence shows that mammoths were more closely related to modern, living elephants than previously4 thought, and some elements were found, such as evidence of inbreeding, that may shed light on why the giant creatures went extinct, researchers reported on Wednesday.

It shows that it is possible to reconstruct the genomes of extinct creatures, they reported in the journal Nature.

"By deciphering this genome we could, in theory, generate data that one day may help other researchers bring the woolly mammoth back to life by inserting the uniquely mammoth DNA sequences into the genome of the modern-day elephant," Stephan Schuster of Pennsylvania State University, who helped lead the research, said in a statement.

"This would allow scientists to retrieve5 the genetic6 information that was believed to have been lost when the mammoth died out, as well as to bring back an extinct species that modern humans have missed meeting by only a few thousand years."

The sequence shows that mammoths, which died out around 10,000 years ago, evolved slowly.

"We discovered that individual woolly mammoths were so genetically7 similar to one another that they may have been especially susceptible8 to being wiped out by a disease, by a change in the climate, or by humans," said Schuster.

The researchers will have to analyze9 the DNA to pinpoint10 some of the precise sequences unique to mammoths, but have some hints.

"Our data suggest that mammoths and modern-day elephants separated around six million years ago, about the same time that humans and chimpanzees separated," added Penn State biologist Webb Miller11, who directed the study.

But mammoths and elephants appear more closely related than humans and chimpanzees are. Miller said the findings can help scientists understand evolution.

The researchers have been pulling DNA out of mummified mammoths and their hair for more than a decade, but because it is so old, the DNA is broken down. It is also contaminated by bacteria and fungi12.

Mammoths offer a better target than most extinct animals because many of their bodies have been frozen since death - some so thoroughly13 that the meat is still edible14.

The Penn State researchers believe they have about 80 percent of its genome complete.

The evidence suggests that woolly mammoths then separated into two groups around 2 million years ago, which eventually became genetically distinct. One went extinct 45,000 years ago, while another survived until 10,000 years ago.

Next in line - perhaps Neanderthals, said Michael Hofreiter of the Max Planck Institute for Evolutionary15 Anthropology16 in Leipzig, Germany.

"The next draft nuclear genome of an extinct species likely to become available is that of our closest relative, the Neanderthal, following on from publication of a complete Neanderthal mitochondrial genome sequence," Hofreiter wrote in a commentary.

Questions:

1. Where did the scientists get the DNA of the woolly mammoth?

2. Why are mammoths an easier target than most extinct animals?

3. How much of the complete mammoth genome do researchers have?

Answers:

1. From its mummified hair.

2. Because many of their bodies have been frozen since death - some so thoroughly that the meat is still edible.

3. They believe they have about 80 percent of the genome.



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1 gene WgKxx     
n.遗传因子,基因
参考例句:
  • A single gene may have many effects.单一基因可能具有很多种效应。
  • The targeting of gene therapy has been paid close attention.其中基因治疗的靶向性是值得密切关注的问题之一。
2 mammoth u2wy8     
n.长毛象;adj.长毛象似的,巨大的
参考例句:
  • You can only undertake mammoth changes if the finances are there.资金到位的情况下方可进行重大变革。
  • Building the new railroad will be a mammoth job.修建那条新铁路将是一项巨大工程。
3 DNA 4u3z1l     
(缩)deoxyribonucleic acid 脱氧核糖核酸
参考例句:
  • DNA is stored in the nucleus of a cell.脱氧核糖核酸储存于细胞的细胞核里。
  • Gene mutations are alterations in the DNA code.基因突变是指DNA密码的改变。
4 previously bkzzzC     
adv.以前,先前(地)
参考例句:
  • The bicycle tyre blew out at a previously damaged point.自行车胎在以前损坏过的地方又爆开了。
  • Let me digress for a moment and explain what had happened previously.让我岔开一会儿,解释原先发生了什么。
5 retrieve ZsYyp     
vt.重新得到,收回;挽回,补救;检索
参考例句:
  • He was determined to retrieve his honor.他决心恢复名誉。
  • The men were trying to retrieve weapons left when the army abandoned the island.士兵们正试图找回军队从该岛撤退时留下的武器。
6 genetic PgIxp     
adj.遗传的,遗传学的
参考例句:
  • It's very difficult to treat genetic diseases.遗传性疾病治疗起来很困难。
  • Each daughter cell can receive a full complement of the genetic information.每个子细胞可以收到遗传信息的一个完全补偿物。
7 genetically Lgixo     
adv.遗传上
参考例句:
  • All the bees in the colony are genetically related. 同一群体的蜜蜂都有亲缘关系。
  • Genetically modified foods have already arrived on American dinner tables. 经基因改造加工过的食物已端上了美国人的餐桌。 来自英汉非文学 - 生命科学 - 基因与食物
8 susceptible 4rrw7     
adj.过敏的,敏感的;易动感情的,易受感动的
参考例句:
  • Children are more susceptible than adults.孩子比成人易受感动。
  • We are all susceptible to advertising.我们都易受广告的影响。
9 analyze RwUzm     
vt.分析,解析 (=analyse)
参考例句:
  • We should analyze the cause and effect of this event.我们应该分析这场事变的因果。
  • The teacher tried to analyze the cause of our failure.老师设法分析我们失败的原因。
10 pinpoint xNExL     
vt.准确地确定;用针标出…的精确位置
参考例句:
  • It is difficult to pinpoint when water problems of the modern age began.很难准确地指出,现代用水的问题是什么时候出现的。
  • I could pinpoint his precise location on a map.我能在地图上指明他的准确位置。
11 miller ZD6xf     
n.磨坊主
参考例句:
  • Every miller draws water to his own mill.磨坊主都往自己磨里注水。
  • The skilful miller killed millions of lions with his ski.技术娴熟的磨坊主用雪橇杀死了上百万头狮子。
12 fungi 6hRx6     
n.真菌,霉菌
参考例句:
  • Students practice to apply the study of genetics to multicellular plants and fungi.学生们练习把基因学应用到多细胞植物和真菌中。
  • The lawn was covered with fungi.草地上到处都是蘑菇。
13 thoroughly sgmz0J     
adv.完全地,彻底地,十足地
参考例句:
  • The soil must be thoroughly turned over before planting.一定要先把土地深翻一遍再下种。
  • The soldiers have been thoroughly instructed in the care of their weapons.士兵们都系统地接受过保护武器的训练。
14 edible Uqdxx     
n.食品,食物;adj.可食用的
参考例句:
  • Edible wild herbs kept us from dying of starvation.我们靠着野菜才没被饿死。
  • This kind of mushroom is edible,but that kind is not.这种蘑菇吃得,那种吃不得。
15 evolutionary Ctqz7m     
adj.进化的;演化的,演变的;[生]进化论的
参考例句:
  • Life has its own evolutionary process.生命有其自身的进化过程。
  • These are fascinating questions to be resolved by the evolutionary studies of plants.这些十分吸引人的问题将在研究植物进化过程中得以解决。
16 anthropology zw2zQ     
n.人类学
参考例句:
  • I believe he has started reading up anthropology.我相信他已开始深入研究人类学。
  • Social anthropology is centrally concerned with the diversity of culture.社会人类学主要关于文化多样性。
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