A world-first completed clinical study by an Australian team has found Kava, a medicinal South Pacific plant, significantly reduced the symptoms of people suffering anxiety. The study, led by the University of Melbourne and published in the Journal of Clinical Psychopharmacology, revealed Kava could be an alternative treatment to pharmaceutical¹ products for the hundreds of thousands of Australians who suffer from Generalised Anxiety Disorders³ (GAD⁴)

 

Lead researcher, Dr Jerome Sarris from Department of Psychiatry⁵ at the University of Melbourne, said GAD is a complex condition that significantly affected⁶ people's day-today lives. Existing medications have a modest clinical effect and new effective options were needed for patients with anxiety. "Based on previous work we have recognised that plant based medicines may be a viable⁷ treatment for patients with chronic⁸ anxiety. In this study we've been able to show that Kava offers a potential natural alternative for the treatment of chronic clinical anxiety. Unlike some other options it has less risk of dependency and less potential for side effects," he said.

 

The study also found that people's genetic⁹ differences (polymorphisms) of certain neurobiological mechanisms¹⁰ called GABA transporters, may modify their response to Kava. "If this finding is replicated¹¹, it may pave the way for simple genetic tests to determine which people may be likely to have a beneficial anxiety-reducing effect from taking Kava," Dr Sarris said.

 

During the eight-week study, 75 patients with clinically diagnosed Generalised Anxiety Disorder² were given Kava or placebo¹², and anxiety levels were regularly assessed. Results showed a significant reduction in anxiety for the Kava group compared to the placebo group at the end of the study.

 

In participants diagnosed with moderate to severe GAD, Kava had an even greater effect in reducing anxiety. Following the completion of the controlled phase, 26 per cent of the Kava group were classified as in remission（缓解期） from their symptoms compared to six per cent of the placebo group.

 

Participants in the Kava group were given tablets twice per day consisting of water-soluble extracted Kava (peeled rootstock) for a total dose of 120mg of kavalactones for the first three-week controlled phase. In cases of non-response this was increased to a double-dose twice per day for the second three-week controlled phase. Participants in the placebo group took matching dummy¹³（虚拟的） tablets in the same manner.

 

Kava was also well tolerated. Results showed no significant differences across the two groups for liver function which had previously¹⁴ been a concern for Kava's medicinal use. In addition there were no considerable adverse¹⁵ reactions that could be attributed to Kava and no difference in withdrawal¹⁶ or addiction¹⁷ between the groups.

 

An additional novel finding of the study, recently published in Phytotherapy Research was that Kava increased women's sex drive compared to those in the placebo group, believed to be due to the reduction of anxiety, rather than any aphrodisiac（春药） effect.

 

Future studies confirming the genetic relationship to therapeutic¹⁸ response, and any libido-improving effects from Kava is now required. Dr Sarris said these significant findings are of importance to sufferers of anxiety and to the South Pacific region which relies on Kava as a major export.

 

The study was funded by the NHMRC and Integria Healthcare who manufacture MediHerb and Thompson's Kava products.

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