Forensic¹ DNA²-based familial search methods may mistakenly identify individuals in a database as siblings³ or parents of an unknown perpetrator（犯罪者）, when in fact they are distant relatives, according to research published August 14 in the open access journal PLOS ONE by Rori Rohlfs and colleagues from the University of California at Berkeley and New York University. Familial searching is a new forensic technique to identify a perpetrator if a crime scene DNA sample has no matches in a DNA database. In such a situation, law enforcement can look for a partial match to a known person in the database -- a "near miss（相近差错）" -- in the hope that the closeness of the genetic⁴ profiles indicates that one of that person's relatives is the perpetrator. Familial searches can reliably distinguish first-degree relatives from unrelated individuals, but may misidentify distant relatives as being immediate⁵ family, according to this new research. As a result, second cousins, half- siblings and other relatives may be identified as siblings. The results suggest a 3-18% chance that a first cousin of a known offender⁶ could be misidentified as a full-sibling using current techniques, and up to a 42% chance that a half-sibling could be misidentified as a full-sibling.

 

The authors conclude that there exist two unanticipated likely outcomes of familial search policies. The study explains these as, "Investigations⁸ may wrongly target the immediate families of known offenders⁹, because officers mistakenly believe that their lead is a first-degree relative. Second, investigations may ultimately probe far more deeply than initially¹⁰ imagined, because once officers are convinced that the source cannot be found among first degree relatives, they will widen their net of investigation⁷ to include more distant relations. Both of these consequences exacerbate¹¹（加剧，恶化） the numerous ethical¹² problems presented by familial searching."

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