Paracrine - cell messengers also called cytokines which are locally acting1, produced by neighbouring cells or the extracellular matrix, as distinct from as distinct from endochrine or hormonal2 messengers.
Parakeratinised - an epithelium in which the superficial cells have not lost their nuclei3, but have become filled with keratin. see also keratinised
Parasympathetic - part of the autonomic nervous system concerned with maintaining routine functions. Always acts as a balance to activity of the sympathetic nervous system.
Pathogenic - able to cause disease.
Pellicle - a thin layer of salivary5 proteins which forms on the surface of enamel6.
Peptide bonds - a covalent bond made between the carbon atom of the carboxyl group of one amino acid and the nitrogen atom from the amine group of another. In the process a molecule7 of water is removed. Peptide bonds allow chains of amino acids to form polypeptides and proteins When peptide bonds are broken apart they need water to reform the amino acids. This process is known as hydrolysis, and occurs during cooking and in digestion8..
Periaquaductal grey - is an integrative centre for inputs9 form the autonomic nervous system, the limbic system and from sensory10 and motor pathways. It has an inhibitory affect on pain transmission due to descending11 connections through the raphe nucleus12 along the corticospinal tract13 to the cells of the dorsal14 horn.
Pericytes- small cells lying next to the endothelial cells of capillaries15 which have the capacity to differentiate16 into osteoblasts.
Periodontal pocket - loss of epithelial attachment17 to the tooth, producing an increase in gingival sulcus depth beyond the normal 1-2 mm.
Periosteum - a connective tissue layer containing osteoblasts on the external aspect of all bones. see alsoendosteum.
Peritubular dentine - see intratubular dentine
pH - a measure of how acid or alkali a solution is. As the pH gets lower, the solution is more acid. At a pH of 7 the solution is neither acid nor alkali. pH is the inverse18 of the logarithm of the concentration of hydrogen ions.
Phagocytosis - the ingestion of small particles, bacteria or viruses into the cell, by engulfing19 it in a vacuole.
Phosphate - a salt in which the negatively charged part is a phosphorus molecule joined to four oxygen molecules20 as PO4.
Phospho-proteins - proteins which contain available phosphate groups.
Phospholipids - are the most common lipids in our cell membranes21. The head group contains a phosphate and is readily soluble22 in water. Phospholipids are also found inmatrix vesicles, and they provide the first step in the synthesis of prostaglandins
Planktonic23 - a form of life style in which an organisms floats freely in a fluid without significant attachment or association with other living forms.
Plaque24 is a film of bacteria in a matrix of salivary and bacterial25 polymers. It can be called a biofilm as it has a complex population of organisms which when mature, reach an ecological26 balance with one another.
Plasma27 - the fluid part of blood, containing proteins and salts, from which the blood cells have been removed. see alsoserum.
Plasmid- a circular piece of DNA28 found in the cell cy lasm of bacteria which is able to reproduce itself independently of it host. Plasmids may transmit a resistance to antibiotics29 from one bacteria to another. They are of great importance in techniques using for recombinant DNA.
Platelet- derived30 growth factor - a cytokine found especially in platelets. It stimulates31 cell proliferation and encourages wound healing.
Platelets - are small colourless discs of cy lasm found in blood. When platelets come into contact with a damaged vessels32 surface they change in several important ways. They begin to swell33, their shape becomes irregular with protruding34 processes, they become sticky and they release an enzyme35 which causes the formation of thromboxane, one of the precursors36 of thrombin. Thromboxane also activates37 nearby platelets, thus starting a positive feedback which rapidly increases the mass of sticky platelets which form a platelet plug. This process accounts for daily damage to capillary38 walls. Damage on a larger scale requires other mechanism39 for haemostasis. Platelets also release serotonin which acts as a powerful vasoconstrictor
Polymers-large molecules made up of many joined units of a more simple molecule. Examples are polysaccharides and polypeptides.
Polypeptides; -chains of amino acids joined by peptide bonds. They are not the size of proteins, but may be biologically very active. Some hormones40 are peptides, such as insulin which has 51 amino-acid residues41. Peptides may also be powerful neurotransmitter substances.
Polyphyodont - continuous replacement42 of teeth with many generations (from "poly" =many; "phylo" = generation and "dont" =teeth). See also diphyodont
Polysaccharides - long molecules made of chains of sugars linked together. Examples are starch43, glycogen and dextrans.
Predentine - the extracellular matrix produced by odontoblasts, which becomes mineralised to form dentine. Similar in structure to osteoid.
Procaryote - a cell in which the genetic44 material is dispersed45 throughout the cell in distinction to a eucaryote which has a nucleus and other organelles. Bacteria and blue-green algae46 are procaryotes
Prognathic- a prominent lower jaw47 which may bring the lower teeth ahead of the upper teeth
Proline- one of 20 amino acids common in proteins. It is a common amino acid of collagen and like lycine must be hydroxylated by ascorbic acid in order to allow the formation of hydrogen bonds which will hold the triple helix together.
Proline-rich proteins - a group of proteins in saliva4 which have the ability to bind48 to calcium49. They provide the protective layer of pellicle on the tooth surfaces by binding50 to the calcium in enamel. They also bind onto microorganism, providing a link between organism and the tooth surface. Proline rich proteins help to de-toxify tanins, which are potentially poisonous plant substances found in tea, and unripe51 fruit.
Prostaglandins - are members of a class of hormones known as the eicosanoids. They are released by cells which have been damaged and have a powerful ability to sensitise nerve endings causing tenderness to the damaged area, and to cause vasoconstriction by contracting the smooth muscle of arterioles. They belong to a group of compounds which have a similar effect on nervous tissue, known asneuropeptides.
Proteins - usually very large molecules, from 10,000 to 200,000 amino acids, which form the structural52 component53 of a cell'smatrix. and cytoskeleton. All enzymes54 are proteins.
Proton - the positively55 charged elements of the nucleus of an atom. A hydrogen atom without its electron amounts to a single proton charge.
Pulp56 - the dental pulp is a connective tissue trapped inside the fully57 formed tooth with just one entry and exit for nerves and vessels, at the apex58 of the root. The characteristic cell of the pulp, is the odontoblast, which lines the walls of the pulp chamber59 and is able to form dentine throughout life.
Pulpitis - inflammation of the dental pulp caused by irritation60 from chemical, physical or bacterial injury, usually transmitted to the pulp via the dentine. It is important for the clinical management of the tooth, to decide whether the pulpitis is reversible, that is will it resolve if the irritation is removed, or whether it has been damaged beyond its capacity to repair.
Pyrophosphate - inhibitors of mineralisation, they may offer up phospate ions in the presence of alkaline phosphatase. Crystals of calcium pyrophosphates are found in abnormal calcification61 of soft tissue, such as the disc of the TM Joint62.
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