Chinese scientists produced the world's first genetically-engineered human blood vessel2 cells, providing a promising3 option for therapeutic4 use.
中国科学家制造出世界第一个基因工程人类血管细胞，为相关治疗带来了希望。
The study published on Thursday in the journal Cell Stem Cell showed that human
vascular5 cell function can be enhanced by editing a single longevity-related
gene1.
Scientists from the Institute of Biophysics of the Chinese Academy of Sciences (CAS), Peking University and the Institute of
Zoology6 of CAS targeted a gene called FOXO3, an important regulator to delay
cellular7 aging, resist stresses and enhance cardiovascular balance.
The technique can also resist the cells'
transformation8 into tumors. The risk of
tumor9 transformation used to be a major concern for the application of the gene-editing technology.
The researchers tested it in a mouse model with blood-shortage or ischemic injury and found that those cells promoted vascular regeneration and resisted tumor transformation both in vitro and in vivo.
They expected to use gene-editing strategies in the future to produce high-quality, safe human vascular cell
grafts10 in a large-scale and
standardized11 manner.
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