艾滋病毒疫苗可靠性被质疑
文章来源:未知 文章作者:meng 发布时间:2009-10-20 05:05 字体: [ ]  进入论坛
(单词翻译:双击或拖选)

Doubts have been raised about the reliability1 of a trial suggesting success for a vaccine2 against HIV.

公众对关于艾滋病毒的疫苗研制成功可靠性的质疑不断浮现。

The search for an HIV vaccine has proved <a href=frustrating3" width="226" border="0" src="/upimg/091020/4_052514_1.jpg" />
The search for an HIV vaccine has proved frustrating

In the large-scale trial in Thailand, a combination of vaccines4 seemed to give volunteers a protective effect of 31%.

The US military and Thai government, who co-sponsored the trial, said the effect was not caused by random5 chance but was statistically7 significant.

But new data, being published at a conference in Paris on Tuesday, is believed to question that assertion(断言,主张).

It was the world's largest clinical trial of a HIV vaccine - involving 16,000 people in Thailand aged8 between 18 and 30.

Among the 8,000 volunteers who had been given the combination of vaccines, 51 had gone on to become infected with the virus.

Of the group given a placebo9(安慰剂), there were 74 positive cases.

The numbers were small, but according to Seth Berkley of the International Aids Vaccine Initiative, the results were "exciting news and a significant scientific achievement".

She said: "Now we have got a vaccine candidate(候选人,求职者) that appears to show a protective effect in humans, albeit10(虽然,即使) partially11."

Lack of detail

But there were concerns as well. Researchers were not able to indicate just how the vaccines were working.

And, as more data was given to scientists, the claims about statistical6 significance began to look increasingly shaky.

Gus Cairns, who works with UK HIV information charity NAM, said: "This particular study was in the awkward(笨拙的,尴尬的) position of producing a result that was only just statistically significant.

"This means there was a one in 26 chance that the results could be due to pure chance - and that this may not reflect anything at all.

"That's difficult. And there is also subset(子集) analysis of this study that if you only look at the people who strictly12 adhered to(坚持 ,依附) the protocol13 - ie took all their vaccine doses - then it becomes not statistically significant."

The problem is that the initial figures given for the numbers infected included all those who got HIV once the trial started, including those who got it in the course of the six-month regime of injections.

But if these were excluded(排除,除外), as they would be in many trials, then the numbers change - and so do the claims of a protective effect.

Study power reduced

These details have been substantiated14 by the US military HIV research programme.

In an update to the study, they indicated that if you looked at the data in this way, it does not reach statistical significance and the study's power is reduced.

Researchers are expected to give a more detailed15 breakdown16 at the Global HIV vaccines meeting in Paris.

Many scientists have been upset that the initial information about the trial came out via a press conference, rather than via a peer reviewed journal.

But according to Dr Aland Bernstein, executive director of the Global HIV vaccine enterprise, the issue of how the information came out does not matter.

"At the end of the day what matters to me is the long run. If that work doesn't hold up that's fine, we'll hear no more of it.

"If it holds up, and we'll only know that over the weeks and months ahead, then it is an important contribution - and whether we heard those results on 24 September or 24 October it doesn't matter in the long run."



点击收听单词发音收听单词发音  

1 reliability QVexf     
n.可靠性,确实性
参考例句:
  • We mustn't presume too much upon the reliability of such sources.我们不应过分指望这类消息来源的可靠性。
  • I can assure you of the reliability of the information.我向你保证这消息可靠。
2 vaccine Ki1wv     
n.牛痘苗,疫苗;adj.牛痘的,疫苗的
参考例句:
  • The polio vaccine has saved millions of lives.脊髓灰质炎疫苗挽救了数以百万计的生命。
  • She takes a vaccine against influenza every fall.她每年秋季接种流感疫苗。
3 frustrating is9z54     
adj.产生挫折的,使人沮丧的,令人泄气的v.使不成功( frustrate的现在分词 );挫败;使受挫折;令人沮丧
参考例句:
  • It's frustrating to have to wait so long. 要等这么长时间,真令人懊恼。
  • It was a demeaning and ultimately frustrating experience. 那是一次有失颜面并且令人沮丧至极的经历。 来自《简明英汉词典》
4 vaccines c9bb57973a82c1e95c7cd0f4988a1ded     
疫苗,痘苗( vaccine的名词复数 )
参考例句:
  • His team are at the forefront of scientific research into vaccines. 他的小组处于疫苗科研的最前沿。
  • The vaccines were kept cool in refrigerators. 疫苗放在冰箱中冷藏。
5 random HT9xd     
adj.随机的;任意的;n.偶然的(或随便的)行动
参考例句:
  • The list is arranged in a random order.名单排列不分先后。
  • On random inspection the meat was found to be bad.经抽查,发现肉变质了。
6 statistical bu3wa     
adj.统计的,统计学的
参考例句:
  • He showed the price fluctuations in a statistical table.他用统计表显示价格的波动。
  • They're making detailed statistical analysis.他们正在做具体的统计分析。
7 statistically Yuxwa     
ad.根据统计数据来看,从统计学的观点来看
参考例句:
  • The sample of building permits is larger and therefore, statistically satisfying. 建筑许可数的样本比较大,所以统计数据更令人满意。
  • The results of each test would have to be statistically independent. 每次试验的结果在统计上必须是独立的。
8 aged 6zWzdI     
adj.年老的,陈年的
参考例句:
  • He had put on weight and aged a little.他胖了,也老点了。
  • He is aged,but his memory is still good.他已年老,然而记忆力还好。
9 placebo placebo     
n.安慰剂;宽慰话
参考例句:
  • The placebo has been found to work with a lot of different cases.人们已发现安慰剂能在很多不同的病例中发挥作用。
  • The placebo effect refers to all the observable behaviors caused by placebo.安慰剂效应是指由安慰剂所引起的可观察的行为。
10 albeit axiz0     
conj.即使;纵使;虽然
参考例句:
  • Albeit fictional,she seemed to have resolved the problem.虽然是虚构的,但是在她看来好象是解决了问题。
  • Albeit he has failed twice,he is not discouraged.虽然失败了两次,但他并没有气馁。
11 partially yL7xm     
adv.部分地,从某些方面讲
参考例句:
  • The door was partially concealed by the drapes.门有一部分被门帘遮住了。
  • The police managed to restore calm and the curfew was partially lifted.警方设法恢复了平静,宵禁部分解除。
12 strictly GtNwe     
adv.严厉地,严格地;严密地
参考例句:
  • His doctor is dieting him strictly.他的医生严格规定他的饮食。
  • The guests were seated strictly in order of precedence.客人严格按照地位高低就座。
13 protocol nRQxG     
n.议定书,草约,会谈记录,外交礼节
参考例句:
  • We must observe the correct protocol.我们必须遵守应有的礼仪。
  • The statesmen signed a protocol.那些政治家签了议定书。
14 substantiated 00e07431f22c5b088202bcaa5dd5ecda     
v.用事实支持(某主张、说法等),证明,证实( substantiate的过去式和过去分词 )
参考例句:
  • The results of the tests substantiated his claims. 这些检验的结果证实了他的说法。
  • The statement has never been substantiated. 这一陈述从未得到证实。 来自《现代汉英综合大词典》
15 detailed xuNzms     
adj.详细的,详尽的,极注意细节的,完全的
参考例句:
  • He had made a detailed study of the terrain.他对地形作了缜密的研究。
  • A detailed list of our publications is available on request.我们的出版物有一份详细的目录备索。
16 breakdown cS0yx     
n.垮,衰竭;损坏,故障,倒塌
参考例句:
  • She suffered a nervous breakdown.她患神经衰弱。
  • The plane had a breakdown in the air,but it was fortunately removed by the ace pilot.飞机在空中发生了故障,但幸运的是被王牌驾驶员排除了。
TAG标签: vaccine HIV trial Thailand
发表评论
请自觉遵守互联网相关的政策法规,严禁发布色情、暴力、反动的言论。
评价:
表情:
验证码:点击我更换图片