Clumps¹ of protein, called plaques²（斑块，瓷片）, in the brain are thought to be a key component³ of the illness.

 

A study, published in the journal Science Translational Medicine, showed that when plaques first developed, the mice started having disrupted sleep.

 

Alzheimer's Research UK argued that if the link was proven it could become a useful tool for doctors.

 

The hunt for early hints that someone is developing Alzheimer's is thought to be crucial for treating the disease. 

 

People do not show problems with their memory or clarity of thought until very late on in the disease. At this point, parts of the brain will have been destroyed, meaning treatment will be very difficult or maybe even impossible.

 

 

It is why researchers want to start early, years before the first symptoms.

 

One large area of research is in plaques of beta amyloid（淀粉体） which form on the brain.

 

Levels of the beta amyloid protein naturally rise and fall over 24 hours in both mice and people. However, the protein forms permanent plaques in Alzheimer's disease.

 

Experiments at Washington University showed that nocturnal mice slept for 40 minutes during every hour of daylight. However, as soon brain plaques started to form the mice were sleeping for only 30 minutes.

 

One of the researchers, Prof David Holtzman, said: "If sleep abnormalities begin this early in the course of human Alzheimer's disease, those changes could provide us with an easily detectable sign of [the disease]."

 

"If these sleep problems exist, we don't yet know exactly what form they take, reduced sleep overall or trouble staying asleep or something else entirely⁵."

 

However, findings in mice do not always apply to people as there are many reasons for disrupted sleep.

 

Dr Marie Janson, from the charity Alzheimer's Research UK, called for more studies in people to see if there was a link between sleeping patterns and Alzheimer's.

 

She added: "There has already been research linking changes in sleep patterns to a decline in thinking skills, but these results suggest that disrupted sleep may also be a warning sign of Alzheimer's. 

 

"If research confirms specific sleep changes as a possible early marker of Alzheimer's, it could prove a useful strategy for doctors to identify patients at risk of the disease."

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